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Duke vs. Syracuse odds, line: 2025 college basketball picks, February 5 best bets by proven model

SportsLine's model has locked in its best bets for an ACC matchup between the Duke Blue Devils and Syracuse Orange on Wednesday

The second-ranked Duke Blue Devils look to extend their winning streak to 16 games when they take on the Syracuse Orange in a key Atlantic Coast Conference matchup on Wednesday. Duke is coming off an 87-70 win over North Carolina on Saturday, while Syracuse defeated California 75-66 that same day. The Blue Devils (19-2, 11-0 ACC), who are 17-0 against unranked opponents, are 6-0 on the road this season. The Orange (10-12, 4-7 ACC), who have lost four of six, are 8-4 on their home court.

Tip-off from JMA Wireless Dome in Syracuse, N.Y., is set for 7 p.m. ET. Duke is an 18.5-point favorite in the latest Duke vs. Syracuse odds from SportsLine consensus, while the over/under for total points scored is set at 143. 

Before making any Duke vs. Syracuse picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 14 of the 2024-25 season on a 208-149 roll (+2275) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

Now, it has simulated Duke vs. Syracuse 10,000 times and the results are in. We can tell you that the model is leaning Over on the total, and it also says one side of the spread hits well over 50% of the time?

Who wins Duke vs. Syracuse, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to see which side of the spread to jump on, all from the model that is on a 208-149 roll on top-rated college basketball picks!

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SportsLine Staff
SportsLine Staff

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