Cubs vs. Brewers odds, line, start time, picks, best bets for NLDS Game 1 matchup from proven model

The Milwaukee Brewers and the Chicago Cubs match up in Game 1 of the NLDS on Saturday. The Cubs were able to handle business and beat the San Diego Padres 2-1 over three games in the Wild Card. On Thursday, Chicago took down the Padres 3-1. Meanwhile, Milwaukee had the No. 1 seed in the NL after winning with an NL-best 97 wins during the regular season. 

First pitch from American Family Field in Milwaukee is set for 2:08 p.m. ET. Milwaukee is a -144 favorite on the money line (risk $144 to win $100) in the latest Cubs vs. Brewers odds from DraftKings Sportsbook, with the Cubs as +119 underdogs. The total number of runs Vegas thinks will be scored, or the over/under, is 7 in the latest MLB odds. 

Before you make any Cubs vs. Brewers picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times.  It enters the 2025 MLB playoffs a profitable 34-29  on top-rated MLB money-line picks this season. It has excelled making home run prop picks this season, returning more than 35 units of profit. Anybody following could have seen strong returns!

The model has simulated Cubs vs. Brewers 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

Who wins Cubs vs. Brewers, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 34-29 roll on top-rated MLB money-line picks!