The No. 2 Ohio State Buckeyes meet the No. 3 Clemson Tigers on Saturday in the College Football Playoff semifinals. Kickoff is set for 8 p.m. ET from State Farm Stadium just outside of Phoenix. The Tigers are 2.5-point favorites and the Over-Under for total points scored is 62.5 in the latest Clemson vs. Ohio State odds. 

Before you make any Ohio State vs. Clemson picks, you need to see what Barrett Sallee has to say. Sallee is a true insider -- a CBS Sports analyst, SiriusXM host, Heisman voter and consistently one of the top CBS Sports experts picking games against the spread -- and his best bets have helped bring in some huge returns. He debuted with SportsLine in 2017 and has delivered in a big way.

This year he's been especially red-hot, going 30-14 on his best bets and going 45-26 on all his college football picks. He also has had a keen eye recently for the tendencies of these two top programs, posting a solid record of 5-1 on picks involving the Tigers or Buckeyes! Anyone who has followed him is WAY UP.

Now, Sallee has locked in on Clemson vs. Ohio State. We can tell you he is leaning Under, but he also says a critical x-factor makes one side of the spread a must-back. You ABSOLUTELY need to see it before locking in any picks of your own.

So who wins Ohio State vs. Clemson? And what critical x-factor makes one side a MUST-BACK? ... Join SportsLine right now to find out which side of the Clemson vs. Ohio State spread you should be all over Saturday, all from the college football insider who has hit over 80 percent of his picks involving these teams!