Chiefs vs. Chargers prediction, odds: football expert reveals 2025 NFL Week 1 picks, analysis
SportsLine expert Mike Tierney, who was 61-39-3 on his NFL picks in 2024, made his prediction for Chiefs vs. Chargers in a Week 1 matchup at Sao Paulo, Brazil
The NFL returns to Brazil for the second consecutive season when the Kansas City Chiefs battle the Los Angeles Chargers in a key AFC West matchup on Friday, Sept. 5. After winning two consecutive Super Bowl championships, the Chiefs fell short in Super Bowl LIX, losing 40-22 to the Philadelphia Eagles. The Chargers (11-6 in 2024), who finished second in the division, are coming off a 32-12 Wild Card loss to the Houston Texans last season. The Chiefs (15-2 in 2024), who have won nine consecutive AFC West titles, have at least one postseason win over the past seven years.
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Kickoff from Arena Corinthians, Sao Paulo, Brazil, is set for 8 p.m. ET. The Chiefs lead the all-time series 71-58-1, including wins in each of the last seven meetings. Kansas City is a 3-point favorite in the latest Chiefs vs. Chargers odds, while the over/under for total points scored is 47. Kansas City is at -170 on the money line (risk $170 to win $100), while Los Angeles is the +143 underdog (risk $100 to win $143).
Before making any Chiefs vs. Chargers picks or NFL predictions, you NEED to hear what SportsLine football expert Mike Tierney has to say.
A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney is 235-189-13 in the NFL the past three seasons, returning $2,505 to $100 players (every bet 1 unit). He hit 61.2% of his ATS picks (61-39-3) last season. Anyone who has followed him could be WAY up!
Now, Tierney has analyzed Chiefs vs. Chargers from every angle and just locked in his picks and predictions.
We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.
Who wins Chiefs vs. Chargers on Friday? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Chargers vs. Chiefs spread to jump on, all from the football expert who was 61-39-3 last season on his NFL picks!
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