Two high-powered offenses in 2019 look to reload again in 2020 as Sun Belt member Louisiana travels to take on No. 23 Iowa State on Saturday. Kickoff is set for noon ET. The Cyclones are 11.5-point favorites, while the over-under for total points scored is 57 in the latest Iowa State vs. Louisiana odds from William Hill. Before making any Louisiana vs. Iowa State picks, you NEED to check out the latest college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It was a perfect 4-0 on top-rated picks in Week 1 of the 2020 college football season, including nailing Army (-3.5) with plenty of room to spare in its 42-0 blowout of MTSU. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on Louisiana vs. Iowa State. We can tell you it's leaning toward the Under, and has generated an against-the-spread pick that is hitting in almost 70 percent of simulations! You ABSOLUTELY need to see it before locking in any college football picks of your own.

Who wins Louisiana vs. Iowa State? And which side of the spread can you bank on in almost 70 percent of simulations? ... Join SportsLine right now to see which side of the Iowa State vs. Louisiana spread to back on Saturday, all from the advanced model that's up more than $3,500 over the past four years on top-rated picks!