SportsLine's advanced computer model simulated 13 of this weekend's biggest games 10,000 times to come up with the projected final scores and key stats.
Here are the projected results:
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SATURDAY, NOVEMBER 3
MICHIGAN STATE AT MARYLAND, 12 P.M. ET
SportsLine Projection Model's score: Michigan State 23, Maryland 19
Vegas line: Michigan State is favored by 2.5 (O/U 46.5)
Projected stats: Provided quarterback Brian Lewerke can return from his shoulder injury, he's projected to throw for 230 yards and 1.38 TDs. He gets some help from running back L.J. Scott (62 rushing yards). Kasim Hill throws for 137 yards and .98 touchdowns for the Terrapins.
LOUISVILLE AT CLEMSON, 12 P.M. ET
SportsLine Projection Model's score: Clemson 46, Louisville 13
Vegas line: Clemson is favored by 38.5 (O/U 61)
Projected stats: The Tigers roll behind quarterback Trevor Lawrence's 269 passing yards and 2.29 touchdown passes. He gets help from running back Travis Etienne's 100 rushing yards and wideout Tee Higgins' 62 receiving yards. Jawon Pass throws for 171 yards for the Cardinals.
NEBRASKA AT OHIO STATE, 12 P.M. ET
SportsLine Projection Model's score: Ohio State 46, Nebraska 22
Vegas line: Ohio State is favored by 17.5 (O/U 72.5)
Projected stats: Nebraska loses despite quarterback Adrian Martinez's 245 passing yards and 1.32 touchdowns. Buckeyes quarterback Dwayne Haskins leads with 239 passing yards and 2.96 TDs. Receiver K.J. HIll gets 51 yards through the air and running back Mike Weber picks up 108 on the ground.
TEXAS A&M AT AUBURN, 12 P.M. ET
SportsLine Projection Model's score: Auburn 27, Texas A&M 18
Vegas line: Auburn is favored by 4 (O/U 49)
Projected stats: The Aggies lose to the Tigers as Kellen Mond's 210 passing yards and .89 touchdown passes aren't enough. Jarrett Stidham throws for 242 yards with 1.33 TDs for Auburn.
SportsLine Projection Model's score: Ole Miss 30, South Carolina 28
Vegas line: Pick'em (O/U 67.5)
Projected stats: In a squeaker, the Rebels win and cover behind quarterback Jordan Ta'amu's 285 passing yards and 1.84 touchdown passes. Supporting him are running back Scottie Phillips (94 rushing yards) and receiver A.J. Brown (79). Jake Bentley throws for 260 and 1.88 touchdowns for the Gamecocks. Wideout Deebo Samuel gains 59 receiving yards.
GEORGIA AT KENTUCKY, 3:30 P.M. ET ON CBS
SportsLine Projection Model's score: Georgia 25, Kentucky 18
Vegas line: Georgia is favored by 8.5 (O/U 44.5)
Projected stats: The Bulldogs roll behind quarterback Jake Fromm's 227 passing yards and 1.45 touchdown passes. He gets help from running back Elijah Holyfield (69 rushing yards) and receiver Jeremiah Holloman (42). Terry Wilson throws for 116 yards and .90 touchdowns for the Wildcats. Benny Snell is Kentucky's lead rusher with 92 yards.
WEST VIRGINIA AT TEXAS, 3:30 P.M. ET
SportsLine Projection Model's score: Texas 30, West Virginia 23
Vegas line: Texas is favored by 2 (O/U 58)
Projected stats: The Longhorns get the cover behind signal caller Sam Ehlinger's solid 298-yard, 1.76-TD performance. His top running back, Keaontay Ingram, racks up 62 ground yards as wideout Lil'Jordan Humphrey gains 87. West Virginia QB Will Grier goes for 286 yards and 1.88 touchdowns.
FLORIDA STATE AT NORTH CAROLINA STATE, 3:30 P.M. ET
SportsLine Projection Model's score: North Carolina State 24, Florida State 20
Vegas line: North Carolina State is favored by 9 (O/U 53.5)
Projected stats: The Wolfpack get past the Seminoles as Ryan Finley's 266 passing yards and 1.43 touchdown passes are just enough. Kelvin Harmon hauls in 80 yards of receptions. Deondre Francois (if he plays through his questionable tag) throws for 238 yards and 1.24 touchdowns for Florida State. Cam Akers is the Seminoles' leading rusher with 57 yards.
SportsLine Projection Model's score: Michigan 27, Penn State 24
Vegas line: Michigan is favored by 10.5 (O/U 53.5)
Projected stats: The Nittany Lions lose the game but cover the spread with quarterback Trace McSorley (expected to play despite a lower-body injury) passing for 180 yards and 1.31 touchdowns. Assisting his efforts are running back Miles Sanders (48 rushing yards) and receiver K.J. Hamler (40). Shea Patterson throws for 187 and 1.41 touchdowns for the Wolverines.
MISSOURI AT FLORIDA, 4 P.M. ET
SportsLine Projection Model's score: Florida 28, Missouri 23
Vegas line: Florida is favored by 6 (O/U 57.5)
Projected stats: The Gators win behind Feleipe Franks' 223 passing yards and 1.51 TD passes. Tigers quarterback Drew Lock racks up 250 passing yards and 1.50 touchdown passes.
DUKE AT MIAMI, 7 P.M. ET
SportsLine Projection Model's score: Miami 25, Duke 20
Vegas line: Miami is favored by 9.5 (O/U 50.5)
Projected stats: Daniel Jones nearly propels Duke to the upset win with 176 passing yards of passing and 1.35 touchdown tosses. Hurricanes quarterback Malik Rosier goes for 277 yards and 1.62 scores, while Travis Homer gains 67 rushing yards.
NOTRE DAME AT NORTHWESTERN, 7:15 P.M. ET
SportsLine Projection Model's score: Notre Dame 30, Northwestern 17
Vegas line: Notre Dame is favored by 9.5 (O/U 53.5)
Projected stats: Clayton Thorson's 187 passing yards and .90 passing touchdowns aren't nearly enough for Northwestern, which fails to cover. Fighting Irish quarterback Ian Book racks up 284 passing yards and 1.72 touchdown passes. Dexter Williams chips in with 85 rushing yards.
ALABAMA AT LSU, 8 P.M. ET
SportsLine Projection Model's score: Alabama 34, LSU 17
Vegas line: Alabama is favored by 14.5 (O/U 54)
Projected stats: Tua Tagovailoa leads the top-ranked Crimson Tide to the win and cover behind 232 passing yards and 1.78 touchdowns. Tide running back Damien Harris racks up 56 yards and teammate Jerry Jeudy collects 66 receiving yards. LSU quarterback Joe Burrow throws for 156 yards and .79 TDs. Running back Nick Brossette gains 53 yards and wideout Justin Jefferson goes for 46.