The top-ranked Clemson Tigers look to continue their ACC dominance when they take on the Wake Forest Demon Deacons in the season opener on Saturday. Kickoff is set for 7:30 p.m. ET from Truist Field in Winston-Salem, N.C. The Tigers are 33-point favorites in the latest Clemson vs. Wake Forest odds from William Hill, while the over-under for total points scored is 60. Before making any Clemson vs. Wake Forest picks of your own, be sure to check out the FBS college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It was a perfect 4-0 on top-rated picks in Week 1 of the 2020 college football season, including nailing Army (-3.5) with plenty of room to spare in its 42-0 blowout of MTSU. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on Clemson vs. Wake Forest. We can tell you it's leaning Under, and it's also generated an against the spread pick that cashes in over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any FBS college football picks of your own.

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