The first full weekend of college football wraps up Monday night when the Notre Dame fighting Irish visit the Louisville Cardinals. Kickoff from Cardinal Stadium is set for 8 p.m. ET. The Irish are 18.5-point favorites and the over-under is 55 in the latest Notre Dame vs. Louisville odds. Before setting your Notre Dame vs. Louisville picks, check out what SportsLine expert Zack Cimini has to say. 

Cimini is a highly respected Las Vegas handicapper who's never afraid to buck conventional wisdom. He uses a new-age approach to excel in multiple sports and has been one of the SportsLine's most successful analysts on an annual basis. He hit nearly 60 percent of his college football spread picks last season, and he is also 3-0 on picks involving Louisville over the past two seasons! Anybody who has been following him is WAY UP.

Now, Cimini has set his sights on Notre Dame vs. Louisville. We can tell you he is leaning Over, but his much stronger play is on the spread. He has identified the critical factor that makes one side of the spread a must-back, and you ABSOLUTELY need to see it before locking in any picks of your own.

So who wins Notre Dame vs. Louisville? And what critical factor makes one side a must-back? ... Join SportsLine right now to find out which side of the Notre Dame vs. Lousiville spread you should be all over on Monday, all from the accomplished expert who is 3-0 on Louisville picks!