The St. Louis Cardinals meet the Chicago Cubs in the first of a three-game weekend series on Friday afternoon. First pitch from Wrigley Field in Chicago is at 2:20 p.m. ET. Chicago is listed as a -135 favorite (risk $135 to win $100) on the money line in the latest Cardinals vs. Cubs odds from William Hill Sportsbook, while the over-under for total runs scored is 9 (see the latest lines for every game on our MLB odds page).

Before making any Cardinals vs. Cubs picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It is off to a fast start in 2021, going 79-62 on top-rated MLB money-line picks through 10 weeks, returning well over $600. Anyone following it has seen HUGE rewards!

Now, it has set its sights on Cardinals vs. Cubs. We can tell you it's leaning Under, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

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