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Cardinals vs. Cubs odds, lines: Proven model reveals MLB picks for Friday, Sept. 24 matchup

SportsLine's Projection Model has generated picks for Friday's matchup between the St. Louis Cardinals and the Chicago Cubs
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The St. Louis Cardinals visit the Chicago Cubs for a double-header on Friday, with the first game set in the afternoon between long-time rivals. First pitch from Wrigley Field in Chicago is at 2:20 p.m. ET. The Cardinals are listed as -140 favorites (risk $140 to win $100) on the money line in the latest Cardinals vs. Cubs odds from Caesars Sportsbook (see the latest lines for every game on our MLB odds page).

Before making any Cardinals vs. Cubs picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, is 193-164 on top-rated MLB money-line picks through 25 weeks in the 2021 season, returning over $500. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some HUGE returns!

The model knows that Cardinals starter J.A. Happ has performed well recently. The 38-year-old has allowed three earned runs or fewer in seven of the last nine games. St. Louis is also fantastic against left-handed pitching, and the Cardinals face a left-hander in this matchup. The Cardinals are No. 2 in the NL in weighted runs created against lefties, and they are No. 1 in the league in slugging percentage against southpaws. 

The model also knows the Cubs have real strengths offensively. Chicago is a top-five team in the National League with 202 home runs, and they also rank near the top of the heap with 78 stolen bases. At the moment, the Cubs have two scalding-hot hitters in Frank Schwindel and Ian Happ, which could benefit them on Friday. Schwindel has seven home runs and a .720 slugging percentage in September, with Happ posting six home runs, four stolen bases and a .681 slugging percentage in his own right.

Now, it has set its sights on Cardinals vs. Cubs. We can tell you the model is projecting 7.7 total runs, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Cardinals vs. Cubs? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the Cardinals vs. Cubs money line you should be all over on Friday, all from the model that is crushing its MLB picks in 2021!

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SportsLine Staff