The BYU Cougars will take on the South Florida Bulls at 10:15 p.m. ET on Saturday, September 25 at LaVell Edwards Stadium. The Cougars are 3-0 overall and 2-0 at home, while South Florida is 1-2 overall and 0-1 on the road. BYU owns two wins over ranked opponents and is 2-1 ATS in 2021, while USF is 1-2 ATS thus far. 

The Cougars are favored by 23 points in the latest BYU vs. South Florida odds from Caesars Sportsbook, and the over-under is set at 52. Before you make any South Florida vs. BYU picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated BYU vs. South Florida 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins BYU vs. South Florida? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!