The Buffalo Bulls and Northern Illinois Huskies open Mid-American Conference play on Wednesday. Kickoff from Huskie Stadium in DeKalb, Ill, is set for 7 p.m. ET. The Bulls are a 14-point favorite in the latest Buffalo vs. Northern Illinois odds from William Hill, while the over-under is 52.5 (find the current college football lines for every game this week in our college football odds section).  

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,100 for $100 players on its top-rated college football picks against the spread. It is a sizzling 31-19 on all top-rated picks through nine weeks of the 2020 college football season, returning over $600 in profit already. Anyone who has followed it has seen HUGE returns.    

Now, it has set its sights on Buffalo vs. Northern Illinois. We can tell you it's leaning Under, and it also says one side of the spread cashes in over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any college football picks of your own.

So who wins Buffalo vs. Northern Illinois? And which side of the spread hits in over 50 percent of the time? ... Join SportsLine right now to find out which side of the Buffalo vs. Northern Illinois spread you should be all over Wednesday, all from the advanced model that has returned over $4,100 on top-rated college football picks!