The Milwaukee Brewers attempt to gain the upper hand in the season series when they host the National League Central-rival Chicago Cubs on Monday for the opener of their three-game set. Milwaukee (46-35), which owns a two-game lead over St. Louis in the division, has split the first 10 meetings this year after going 15-4 against Chicago in 2021. The Cubs (32-47) went 2-7 at Milwaukee last season and were outscored 20-4 while losing two of three there earlier this campaign. First pitch at American Family Field is set for 4:10 p.m. ET.

Milwaukee is listed as a -145 favorite (risk $145 to win $100) on the money line in the latest Brewers vs. Cubs odds from Caesars Sportsbook, while the over-under for total runs scored is 8.5 (see the latest lines for every game on our MLB odds page).

Before making any Cubs vs. Brewers picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and is 271-232 on top-rated MLB money-line picks since the start of the 2021 season, returning well over $500 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

The model knows Milwaukee is coming off a 2-0 victory at Pittsburgh on Sunday that concluded a 4-2 road trip. The Brewers were limited to five hits, but one was a two-run home run by Omar Narvaez in the fifth inning that proved to be all the offense the team needed to post its sixth win in eight overall contests. Milwaukee scored a total of 32 runs in the four-game series but came away with only a split.

The model also knows Chicago had its season high-tying four-game winning streak halted Sunday as it dropped a 4-2 home decision against Boston in 11 innings. Patrick Wisdom continued his power surge by belting a solo homer in the eighth inning that forged a 2-2 tie. The 30-year-old third baseman has hit three of his team-high 17 shots over his last four contests and also tops the Cubs with 45 RBI - eight of which have been recorded in the four-game span.

Now, it has set its sights on Brewers vs. Cubs. We can tell you the model is leaning under on the total, and it also says one side of the money line has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Brewers vs. Cubs? And which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Cubs vs. Brewers run line you should be all over on Monday, all from the model on a roll on MLB picks!