Arizona vs. Kansas State prediction, odds, line, spread, start time: 2025 college football picks, Week 3 best bets from proven model

The Arizona Wildcats (2-0) are set to host the Kansas State Wildcats (1-2) in a Big 12 showdown on Friday night. Arizona is looking to build off its 48-3 blowout win over Weber State. Arizona has won its two games this season by a combined score of 88-9. Kansas State is looking to bounce back from a 24-21 upset loss to Army in its last outing. Both teams have a bye week following this game. 

Kickoff from Arizona Stadium in Tucson is at 9 p.m. ET. Kansas State is a 1.5-point favorite in the latest Arizona vs. Kansas State odds, while the over/under for total points scored is 54.5.

Before making any Kansas State vs. Arizona picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 31-19 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated Arizona vs. Kansas State 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits in over 50% of computer simulations!

So who wins Kansas State vs. Arizona, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!