Alabama vs. Missouri odds, line: 2025 college football picks for Week 7 predictions from proven model

A Top-25 SEC matchup on Saturday pits the No. 8 Alabama Crimson Tide versus the No. 14 Missouri Tigers. Alabama (4-1, 2-0 in SEC) is coming off back-to-back wins over ranked squads in Georgia and Vanderbilt, with the Tide upending the Commodores 30-14 last week. Missouri (5-0, 1-0) has played just two Power Conference programs thus far and had a bye last week after defeating UMass, 42-6, the previous Saturday. Bama shut out Mizzou, 34-0, last season.

Kickoff is at noon ET from Memorial Stadium in Columbia, Mo. The Tide are 3.5-point favorites in the latest Missouri vs. Alabama odds, while the over/under for total points scored is 51.5. 

Before making any Alabama vs. Missouri picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 38-25 combined on money-line and over/under picks since the beginning of 2024. Anyone following it could have seen impressive returns.

The model has simulated Missouri vs. Alabama 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Alabama vs. Missouri, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the Missouri vs. Alabama spread you need to jump on, all from the computer model that has crushed its college football picks!