The No. 2 Louisville Cardinals look to stay hot when they host the South Carolina Upstate Spartans in a non-conference college basketball matchup on Wednesday. Tip-off from the KFC Yum! Center in Louisville is set for 7 p.m. ET. The Cardinals are favored by 36, while the Over-Under for total points scored is set at 140.5. Before making any Louisville vs. South Carolina Upstate picks of your own, be sure to check out the college basketball predictions from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, has crushed its top-rated against-the-spread picks the past three years, returning $2,770 to $100 players. Anybody who has followed it has seen huge returns.

Now, it has set its sights on South Carolina Upstate vs. Louisville. We can tell you it's leaning over, but it's also generated an against the spread pick that hits in nearly 70 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks of your own.

So who wins Louisville vs. South Carolina Upstate? And which side of the spread can you bank on in nearly 70 percent of simulations? ... Join SportsLine right now to find out which side of the South Carolina Upstate vs. Louisville spread you should be all over on Wednesday, all from the model that returned more than $2,700 on top-rated college basketball picks the last three seasons!