No. 8 Seton Hall will try to clinch its first Big East regular-season title since 1993 when the Pirates host No. 14 Villanova (22-7) on Wednesday night. Tipoff is at 8:30 p.m. ET. The Pirates are four-point favorites, while the over-under is 140.5. Before making any Villanova vs. Seton Hall picks of your own, you MUST see what SportsLine's proven model has to say.

This model, which simulates every game 10,000 times, has crushed its top-rated college basketball picks against the spread the past three years, returning $2,770 to $100 players. It also entered Week 18 of the 2019-20 season on a 72-48 run on all top-rated college basketball picks. Anybody who followed it has seen some huge returns.

Now, the model has locked in on Seton Hall vs. Villanova. We can tell you it's leaning Over, and it also has revealed a VERY STRONG against-the-spread pick that is hitting in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks of your own.

So who wins Villanova vs. Seton Hall? And which side of the spread is hitting in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Villanova vs. Seton Hall spread you should be all over Wednesday, all from the advanced model on a 72-48 run on its top-rated college basketball picks!