It's the latest edition of one of college football's most storied rivalries when the Southern Cal Trojans travel to South Bend to face the ninth-ranked Notre Dame Fighting Irish on Saturday. Kickoff from Notre Dame Stadium is set for 7:30 p.m. ET. Notre Dame is a 10.5-point favorite in the latest USC vs. Notre Dame odds, while the over-under is 58.5. Before considering your USC vs. Notre Dame picks, be sure to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times, and those who have followed it have seen huge returns. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,300 for $100 players on its top-rated college football against-the-spread picks.  

The model enters Week 7 of the 2019 season on a strong run, going 68-42 on its top-rated college football picks. It also called Georgia (-27.5) covering against Tennessee and California (+21) easily staying well within the spread against Oregon last week. Anybody who has been following it is WAY UP.

Now, it has set its sights on USC vs. Notre Dame. We can tell you it's leaning under, and it's also generated an extremely strong against the spread pick that cashes in well over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college football picks of your own.

Who wins USC vs. Notre Dame? And which side of the spread is hitting well over 60 percent of the time? ... Join SportsLine right now to see which side of the USC vs. Notre Dame spread to back on Saturday, all from the advanced model on a 68-42 run on top-rated picks!