The Louisville Cardinals will take on the Western Kentucky Hilltoppers at 8 p.m. ET on Saturday at Cardinal Stadium. The Cardinals went 8-5 last season, with a 38-28 victory over Mississippi State in the Music City Bowl. The Hilltoppers went 9-4 in 2019, including a 23-20 win over Western Michigan in the First Responder Bowl.

The Cardinals are favored by 11.5 points in the latest Louisville vs. Western Kentucky odds, down from 13.5 points at the open, in the latest college football odds from William Hill. The Over-Under is set at 58, points, up two points from the open. Before you make any Western Kentucky vs. Louisville picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It was a perfect 4-0 on top-rated picks in Week 1 of the 2020 college football season, including nailing Army (-3.5) with plenty of room to spare in its 42-0 blowout of MTSU. Anyone who has followed it has seen huge returns.

Now, it has simulated Louisville vs. Western Kentucky 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Louisville vs. Western Kentucky? And which side of the spread is hitting in well over 50 percent of simulations? ...Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!