The DePaul Blue Demons and the  No. 12 Villanova Wildcats are set to square off in a Big East matchup at 9 p.m. ET Wednesday at Wintrust Arena. The Blue Demons are 13-12 overall and 9-6 at home, while Villanova is 19-6 overall and 5-3 on the road. Villanova is third in the Big East; DePaul is 10th. The Wildcats are favored by 4,5 points in the latest DePaul vs. Villanova odds, while the Over-Under is set at 141. Before you make any Villanova vs. DePaul picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

This model, which simulates every game 10,000 times, has crushed its top-rated college basketball picks against the spread the past three years, returning $2,770 to $100 players. It also entered Week 16 of the 2019-20 season on a 54-30 run on all top-rated college basketball picks. Anybody who followed it has seen huge returns.

Now, it has simulated DePaul vs. Villanova 10,000 times and the results are in. We can tell you that the model is leaning Over, and it has generated a pick that hits in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins DePaul vs. Villanova? And which side of the spread hits in well over 50 percent of simulations? ...Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!