The Philadelphia 76ers will take on the Detroit Pistons at 7 p.m. ET Saturday at Wells Fargo Center. The 76ers are 46-21 overall and 26-7 at home, while Detroit is 20-47 overall and 7-28 on the road. Philadelphia is favored by 10.5 points in the latest Sixers vs. Pistons odds from William Hill Sportsbook, and the Over-Under is set at 218.5. Before you make any Pistons vs. Sixers picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned over $9,200 in profit on its top-rated NBA picks over the past two-plus seasons. The model is up over $1,200 on its top-rated picks this season and entered Week 20 of the 2020-21 NBA schedule on a stunning 97-62 roll on top-rated NBA picks against the spread dating back to last season. Anybody who has followed it has seen huge returns.

Now, it has simulated Sixers vs. Pistons 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Sixers vs. Pistons? And which side of the spread is hitting in well over 60 percent of simulations? ...Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks... If you're already a member, see the picks below!