The Oklahoma Sooners and the Iowa State Cyclones are set to square off in a Big 12 matchup at 9 p.m. ET Wednesday at Lloyd Noble Center. The Sooners are 15-8 overall and 10-1 at home, while Iowa State is 10-13 overall and 0-7 on the road. The Sooners are favored by 10-points in the latest Oklahoma vs. Iowa State odds, while the Over-Under is set at 143. Before you make any Iowa State vs. Oklahoma picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

This model, which simulates every game 10,000 times, has crushed its top-rated college basketball picks against the spread the past three years, returning $2,770 to $100 players. It also enters Week 15 of the 2019-20 season on a 42-27 run on all top-rated college basketball picks. Anybody who followed it has seen huge returns.

Now, it has simulated Oklahoma vs. Iowa State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 70 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Oklahoma vs. Iowa State? And which side of the spread is hitting in 70 percent of simulations? ... Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!