The Memphis Tigers and the East Carolina Pirates are set to square off in an American Athletic matchup at 7 p.m. ET Wednesday at FedExForum. The Tigers are 17-8 overall and 12-3 at home, while East Carolina is 10-16 overall and 1-8 on the road. Memphis is sixth in the American Athletic; East Carolina is 11th. The Tigers are favored by 13 points in the latest Memphis vs. East Carolina odds, while the Over-Under is set at 141. Before you make any East Carolina vs. Memphis picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

This model, which simulates every game 10,000 times, has crushed its top-rated college basketball picks against the spread the past three years, returning $2,770 to $100 players. It also entered Week 16 of the 2019-20 season on a 54-30 run on all top-rated college basketball picks. Anybody who followed it has seen huge returns.

Now, it has simulated Memphis vs. East Carolina 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread has all the value. You absolutely need to see it before locking in your own picks.

So who wins Memphis vs. East Carolina? And which side of the spread has all the value? ...Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!