An ACC battle is on tap between the Notre Dame Fighting Irish and the No. 21 Duke Blue Devils at 9 p.m. ET Wednesday at Purcell Pavilion at the Joyce Center. Notre Dame is 2-2 overall and 1-1 at home, while the Blue Devils are 2-2 overall and 0-0 on the road. The Blue Devils are favored by 3.5 points in the latest Notre Dame vs. Duke odds from William Hill, and the Over-Under is set at 146. Before you make any Duke vs. Notre Dame picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of almost $2,600 for $100 players on its top-rated college basketball picks against the spread. It's also off to a fast start in the 2020-21 season, going 8-4 on all its top-rated picks and returning well over $300. Anyone who has followed it has seen huge returns.

Now, it has simulated Notre Dame vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Notre Dame vs. Duke? And which side of the spread is hitting in almost 70 percent of simulations? ...Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!