Buffalo will take on Penn State at 7:30 p.m. ET on Saturday at Beaver Stadium. Penn State is favored by 30.5 in the latest Buffalo vs. Penn State odds, while the Over-Under is 56. Before you make any Buffalo vs. Penn State picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every FBS college football game 10,000 times, and those who have followed it have seen massive returns. Over the past four years, this proprietary computer model has generated a jaw-dropping $4,530 profit for $100 bettors on its top-rated spread picks. The model enters Week 2 of the 2019 college football season on a blistering 52-31 run on all top-rated picks. It also called Auburn (-3.5) covering against Oregon and Alabama (-34) covering a nearly five-touchdown spread against Duke in Week 1. Anybody who has been following it is way up.

Now, it has simulated Penn St. vs. Buffalo 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Penn St. vs. Buffalo? And which side of the spread is hitting in almost 60 percent of simulations? ...Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.