An NFC West rivalry game is on tap between the San Francisco 49ers (0-1) and the Seattle Seahawks (1-0) at 4:05 p.m. ET on Sunday at Levi's Stadium in Santa Clara. The 49ers are coming off a disappointing 19-10 road loss to the Chicago Bears, while the Seahawks are coming off a thrilling 17-16 win over Russell Wilson and Denver Broncos on Week 1 Monday Night Football. San Francisco quarterback Trey Lance will be looking to rebound from an up and down performance in horrible conditions in Chicago.

San Francisco is favored by 9 points in the latest 49ers vs. Seahawks odds from Caesars Sportsbook, and the over/under is set at 39.5. Before you make any Seahawks vs. 49ers picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated 49ers vs. Seahawks 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins 49ers vs. Seahawks? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!