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    49ers vs. Panthers odds, line, spread: Proven model reveals NFL picks, predictions for Week 5, 2022

    The SportsLine Projection Model has simulated Carolina Panthers vs. San Francisco 49ers 10,000 times and revealed its Week 5 NFL picks
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    The San Francisco 49ers (2-2) will try to build upon their impressive Monday Night Football victory when they visit the Carolina Panthers (1-3) as part of the Week 5 NFL schedule. Kickoff from Bank of America Stadium in Charlotte, N.C., is set for 4:05 p.m. ET. San Francisco is a 6.5-point favorite in the latest 49ers vs. Panthers odds from Caesars Sportsbook, and the over/under for total points scored is 40. Sunday's showdown will be televised on CBS and streamed live in select markets on Paramount+ with their MUST-HAVE Premium plan. Plus, you can watch games on ANY device and get 30 days free with the promo code NFLONCBS.

    You can catch all your local NFL on CBS games on Paramount+, which now has two plans. The Essential Plan costs $4.99 per month to access Paramount's catalog of movies and TV shows with limited advertisements, plus your live local NFL games, international soccer and more. The Premium Plan is $9.99 per month and you can watch your local CBS live stream with no ads, on demand and the ability to download episodes for offline viewing. Plus, until the end of October, you can get 30 days free with the promo code NFLONCBS (expires 10/31/22), so sign up now here.

    Before making any Panthers vs. 49ers picks or any other NFL predictions, you NEED to see what the SportsLine Projection Model has to say.

    The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2022 NFL season on an incredible 140-105 run on top-rated NFL picks that dates back to the 2017 season.

    The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

    Now, it has simulated 49ers vs. Panthers 10,000 times and the results are in. We can tell you that the model is leaning Under on the total, and it also says one side of the spread hits over 50% of the time! You ABSOLUTELY need to see it before locking in your own picks. And don't forget you may be able to stream the game on Paramount+ on ANY DEVICE!

    Who wins Panthers vs. 49ers? And which side of the spread hits over 50% of the time? ... Join SportsLine right now to see which side of the 49ers vs. Panthers spread to jump on, all from the model that has crushed its NFL picks!

    GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!

    JOIN NOW
    SportsLine Staff

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