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    49ers vs. Cardinals odds, line, spread: Proven model reveals NFL picks, predictions for Week 9, 2021

    The SportsLine Projection Model simulated the Week 9 game between Baltimore and Minnesota 10,000 times.
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    An NFC West battle is on tap between the San Francisco 49ers and the Arizona Cardinals at 4:25 p.m. ET on Sunday at Levi's Stadium. San Francisco is 3-4 overall and 0-3 at home, while Arizona is 7-1 overall and 4-0 on the road. 

    San Francisco is favored by 2.5 points in the latest 49ers vs. Cardinals odds from Caesars Sportsbook, and the over-under is set at 45.5. Before you make any Cardinals vs. 49ers picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

    The model, which simulates every NFL game 10,000 times, is up almost $7,800 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 9 of the 2021 season on an incredible 128-86 run on top-rated NFL picks that date back to the 2017 season. The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY up.

    Now, it has simulated 49ers vs. Cardinals 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

    So who wins 49ers vs. Cardinals? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!

    GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!

    JOIN NOW
    SportsLine Staff

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