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2022 NCAA Tournament Sweet 16 Simulation: Model on epic run reveals March Madness bracket picks, predictions

In this bracket, the team that wins more than 50 percent of computer simulations is picked to advance each round. Our optimal bracket beat over 92% of CBS Sports Bracket Challenge players two of the last three tournaments
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No. 3 seed Purdue advances from the East Region of the 2022 NCAA Tournament bracket. Despite beating Kentucky and Murray State, Saint Peter's has less than a 0.1 percent chance of winning it all in our simulations, while Purdue wins the title nearly seven percent of the time. UCLA wins straight-up against North Carolina in 60 percent of simulations.

Get every pick, every play, every upset and fill out the rest of your bracket with our help! ... Join SportsLine now to see which underdog wins in well over 60 percent of simulations in the Sweet 16 and find out which shocking team makes a run to the championship game, all from the model that nailed 17 upsets by double-digit seeds and beat over 92% of bracket players two of the last three tournaments!

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SportsLine Staff