ANALYSIS: This Syracuse squad really missed not having traditional non-conference play last season and will be locked in on getting this game right against a MAC school that got very little experience in 2020. Syracuse was favored a single time in 2020. FBS teams that are favored in their season opener after having been favored two or fewer times last season are 123-93-6 ATS. The times in which the Orange have been favored recently have gone quite well. Syracuse is 5-1-1 ATS since November 2018 as a favorite.