Simulation Picks
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Expert Picks
Fighting Irish quarterback Ian Book had a full offseason as the unquestioned starter after leading this team to the CFP, and has wide receiver Chase Claypool back as one of his primary weapons outside. The duo should light up a Louisville defense that is completely devoid of talent.
Louisville is no stranger to opening up the season against elite competition. That has become a problem since the departure of Lamar Jackson as the Cardinals quickly fell to a disastrous season in 2018. With a new coach in Scott Satterfield, the Cardinals will be no match for the potent Irish. Grab Notre Dame.
The weekend will come to a close in Louisville on Labor Day, and it will end in front of a fired up Louisville crowd hosting the Irish in the first game of the Scott Satterfield era. Now, I don't think Louisville has much of a shot at winning this game, but they'll be fired up for this one, and Notre Dame has a lot of new faces in important places. The Cards do enough to stay within this number.