| Round 1 |
| Pick | Team | Player | Pos | Drafted From (League) |
| 1 | Tampa Bay | Steve Stamkos | C | Sarnia (OHL) |
| 2 | Los Angeles | Drew Doughty | D | Guelph (OHL) |
| 3 | Atlanta | Zach Bogosian | D | Peterborough (OHL) |
| 4 | St. Louis | Alex Pietrangelo | D | Niagara (OHL) |
| 5 | Toronto (from New York Islanders) | Luke Schenn | D | Kelowna (WHL) |
| 6 | Columbus | Nikita Filatov | LW | CSKA (Russia) |
| 7 | Nashville (from Toronto via New York Islanders) | Colin Wilson | C | Boston University (Hockey East) |
| 8 | Phoenix | Mikkel Boedker | LW | Kitchener (OHL) |
| 9 | New York Islanders (from Florida via Nashville) | Joshua Bailey | C | Windsor (OHL) |
| 10 | Vancouver | Cody Hodgson | C | Brampton (OHL) |
| 11 | Chicago | Kyle Beach | C | Everett (WHL) |
| 12 | Buffalo (from Edmonton via Los Angeles) | Tyler Myers | D | Kelowna (WHL) |
| 13 | Los Angeles (from Buffalo) | Colten Teubert | D | Regina (WHL) |
| 14 | Carolina | Zach Boychuk | C | Lethbridge (WHL) |
| 15 | Ottawa (from Nashville) | Erik Karlsson | D | Frolunda Jr. (Sweden) |
| 16 | Boston | Joe Colborne | C | Camrose (AJHL) |
| 17 | Anaheim (from Calgary via Los Angeles) | Jake Gardiner | D | Minnetonka (Minn. H.S.) |
| 18 | Nashville (from Ottawa) | Chet Pickard | G | Tri-City (WHL) |
| 19 | Philadelphia (from Colorado via Columbus) | Luca Sbisa | D | Lethbridge (WHL) |
| 20 | New York Rangers | Michael Del Zotto | D | Oshawa (OHL) |
| 21 | Washington (from New Jersey) | Anton Gustafsson | C | Frolunda Jr. (Sweden) |
| 22 | Edmonton (from Anaheim) | Jordan Eberle | C | Regina (WHL) |
| 23 | Minnesota (from Washington via New Jersey) | Tyler Cuma | D | Ottawa (OHL) |
| 24 | New Jersey (from Minnesota) | Mattias Tedenby | LW | HV 71 (Sweden) |
| 25 | Calgary (from Montreal) | Greg Nemisz | C | Windsor (OHL) |
| 26 | Buffalo (from San Jose) | Tyler Ennis | C | Medicine Hat (WHL) |
| 27 | Washington (from Philadelphia) | John Carlson | D | Indiana (USHL) |
| 28 | Phoenix (from Dallas via Anaheim) | Viktor Tikhonov | LW | Cherepovets (Russia) |
| 29 | Atlanta (from Pittsburgh) | Daultan Leveille | C | St. Catharines (GHL) |
| 30 | Detroit | Thomas McCollum | G | Guelph (OHL) |
