| Last updated: Tue, November 18, 2008, 12:50 EST |
| Monday, November 17, 2008 |
| Team | Player | Transaction |
| Cincinnati Bengals | Abdul Hodge | Placed on IR, arm |
| Cincinnati Bengals | Nate Livings | Activated from the Practice Squad |
| Cincinnati Bengals | Digger Bujnoch | practice squad addition |
| Detroit Lions | LaMarcus Hicks | cut |
| New England Patriots | Darrell Robertson | practice squad addition |
| New England Patriots | Tyson DeVree | Activated from the Practice Squad |
| New England Patriots | Terrence Wheatley | Placed on IR, wrist |
| Tampa Bay Buccaneers | John Lynch | signed |
| Tampa Bay Buccaneers | John Lynch | retired |
| Sunday, November 16, 2008 |
| Team | Player | Transaction |
| New Orleans Saints | Buck Ortega | Activated from the Practice Squad |
| Saturday, November 15, 2008 |
| Team | Player | Transaction |
| Miami Dolphins | Rob Ninkovich | Activated from the Practice Squad |
| Miami Dolphins | Matt McChesney | Placed on IR, knee |
| New Orleans Saints | Brian Young | Placed on IR, knee |
| New Orleans Saints | Buck Ortega | Activated from the Practice Squad |
| Pittsburgh Steelers | Roy Lewis | Activated from the Practice Squad |
| Pittsburgh Steelers | Dallas Baker | cut |
| San Diego Chargers | Corey Clark | cut |
| San Diego Chargers | Tra Battle | Activated from the Practice Squad |
| Seattle Seahawks | Jamar Adams | Activated from the Practice Squad |
| Seattle Seahawks | Jeb Putzier | cut |
| Thursday, November 13, 2008 |
| Team | Player | Transaction |
| Green Bay Packers | Anthony Toribio | practice squad addition |
| Green Bay Packers | Fred Bledsoe | practice squad deletion |
| Indianapolis Colts | Brandon Sumrall | practice squad deletion |
| Kansas City Chiefs | Omar Cuff | practice squad deletion |
| Kansas City Chiefs | Michael Grant | practice squad deletion |
| Kansas City Chiefs | Jermaine McGhee | practice squad deletion |
| Wednesday, November 12, 2008 |
| Team | Player | Transaction |
| Atlanta Falcons | Brandon Miller | Activated from the Practice Squad |
| Atlanta Falcons | Adam Jennings | cut |
| Atlanta Falcons | Chandler Williams | practice squad addition |
| Buffalo Bills | Chris Denman | cut |
| Buffalo Bills | Dustin Fox | practice squad addition |
| Cincinnati Bengals | Geoffrey Pope | practice squad addition |
| Detroit Lions | Antonio Smith | practice squad addition |
| Detroit Lions | Brandon Middleton | cut |
| Detroit Lions | Adam Jennings | acquired from waivers |
| Detroit Lions | Darian Barnes | cut |
| Detroit Lions | Drew Henson | cut |
| Detroit Lions | John Standeford | re-signed |
| Kansas City Chiefs | Kyle Shotwell | practice squad addition |
| Kansas City Chiefs | Jason Babin | signed |
| Kansas City Chiefs | Jackie Battle | practice squad addition |
| Miami Dolphins | Kirk Barton | practice squad addition |
| New Orleans Saints | Remi Ayodele | cut |
| New Orleans Saints | David Pittman | signed |
| New Orleans Saints | David Kirtman | practice squad addition |
| New Orleans Saints | Ben Moffitt | practice squad deletion |
| Oakland Raiders | Justin Miller | acquired from waivers |
| Oakland Raiders | John Madsen | cut |
| Oakland Raiders | Jeff Otis | practice squad addition |
| San Diego Chargers | Michael Bennett | signed |
| San Diego Chargers | Derek Smith | cut |
| San Francisco 49ers | Mark Bradford | practice squad addition |
| Seattle Seahawks | Trent Shelton | practice squad addition |
| Seattle Seahawks | Courtney Taylor | Activated from the Practice Squad |
| St. Louis Rams | Darius Walker | practice squad deletion |
| Tampa Bay Buccaneers | Michael Bennett | cut |
| Tampa Bay Buccaneers | Maurice Stovall | Placed on IR, hamstring |
| Tampa Bay Buccaneers | Brian Clark | Activated from the Practice Squad |
| Tampa Bay Buccaneers | Marc Magro | practice squad addition |
| Tuesday, November 11, 2008 |
| Team | Player | Transaction |
| Baltimore Ravens | Chris McAlister | Placed on IR, knee |
| Baltimore Ravens | Dawan Landry | Placed on IR, shoulder/neck |
| Baltimore Ravens | Ernie Wheelwright | practice squad addition |
| Baltimore Ravens | Marcus Maxwell | signed |
| Baltimore Ravens | Robert McCune | signed |
| Chicago Bears | Terrence Holt | cut |
| Chicago Bears | Ervin Baldwin | Activated from the Practice Squad |
| Cincinnati Bengals | J.D. Runnels | practice squad deletion |
| Denver Broncos | Tatum Bell | signed |
| Denver Broncos | Glenn Martinez | cut |
| Detroit Lions | Aveion Cason | re-signed |
| Kansas City Chiefs | Ingle Martin | practice squad addition |
| Kansas City Chiefs | Larry Johnson | suspension lifted |
| Miami Dolphins | Brannon Condren | cut |
| Pittsburgh Steelers | Donovan Woods | practice squad addition |
| Pittsburgh Steelers | Grant Mason | practice squad deletion |
| Pittsburgh Steelers | Donovan Woods | cut |
| Pittsburgh Steelers | Fernando Bryant | signed, One-year contract |
| Seattle Seahawks | Keary Colbert | cut |
| Monday, November 10, 2008 |
| Team | Player | Transaction |
| Cincinnati Bengals | Geoffrey Pope | cut |
| Denver Broncos | Ryan Torain | Placed on IR, left knee |
| Denver Broncos | Alex Haynes | signed/unrestricted free agent |
| Miami Dolphins | Courtney Bryan | signed |
| Miami Dolphins | Todd Lowber | practice squad addition |
| New Orleans Saints | Leigh Torrence | acquired from waivers |
| New Orleans Saints | Mike McKenzie | Placed on IR, fractured right kneecap |
| New York Jets | Ty Law | signed, One-year contract |
| New York Jets | Justin Miller | cut |
| Pittsburgh Steelers | Ryan Mundy | practice squad addition |
| Tampa Bay Buccaneers | Donte Nicholson | signed |
| Tampa Bay Buccaneers | Kyle Shotwell | practice squad deletion |
| Tampa Bay Buccaneers | Brian Clark | practice squad addition |
| Tampa Bay Buccaneers | Brian Clark | cut |
