| Date | Player | Pos. | Transaction |
| 9/4 | Glenn Pakulak | P | practice squad deletion |
| 9/4 | Daunte Culpepper | QB | retired |
| 9/3 | Jonathan Holland | WR | practice squad addition |
| 9/3 | Darrick Brown | S | practice squad addition |
| 9/3 | Greyson Gunheim | DE | practice squad addition |
| 9/3 | Glenn Pakulak | P | practice squad addition |
| 9/3 | Louis Rankin | RB | practice squad addition |
| 9/3 | Marcel Reece | RB | practice squad addition |
| 9/3 | Darrell Strong | TE | practice squad addition |
| 9/3 | Brandon Torrey | T | practice squad addition |
| 9/3 | Luke Lawton | RB | signed |
| 9/3 | Robert Thomas | LB | cut |
| 9/3 | Derrick Gray | DE | practice squad addition |
| 9/2 | William Joseph | DT | cut |
| 9/1 | Ashley Lelie | WR | signed, One-year contract |
| 8/25 | Greg Spires | DE | cut |
| 8/25 | Grant Irons | LB | cut |
| 8/25 | Jarrod Cooper | S | cut |
| 8/25 | Oren O'Neal | RB | Placed on IR, left knee |
| 8/25 | John Bowie | CB | Placed on IR, knee |
| 8/25 | Luke Lawton | RB | acquired from waivers |
| 8/25 | Drew Carter | WR | Placed on IR, left knee |
| 8/25 | Marviel Underwood | S | signed |
| 8/14 | Edgerton Hartwell | LB | cut |
| 8/14 | Glenn Pakulak | P | signed |
| 8/12 | Greg Wesley | S | cut |
| 8/11 | Adam Archuleta | S | signed, One-year contract |
| 8/8 | Aaron Elling | K | signed |
| 7/24 | Nnamdi Asomugha | CB | re-signed/franchise, One-year tender offer |
| 7/23 | Arman Shields | WR | signed/draft choice |
| 7/23 | Trevor Scott | DE | signed/draft choice |
| 7/22 | William Buchanon | WR | cut |
| 7/22 | Greg Wesley | S | signed/unrestricted free agent, One-year contract |
| 7/21 | Jonathan Palmer | T | cut |
| 6/12 | Grant Irons | LB | signed/unrestricted free agent |
| 6/11 | Tony Jackson | RB | signed |
| 6/6 | Darren McFadden | RB | signed/draft choice, Six-year contract |
| 5/22 | Marques Tuiasosopo | QB | signed/unrestricted free agent |
| 5/20 | Akbar Gbaja-Biamila | LB | cut |
| 5/20 | Stuart Schweigert | S | cut |
| 5/13 | Duane Starks | CB | cut |
| 5/10 | Greg Spires | DE | signed, One-year contract |
| 5/3 | Edgerton Hartwell | LB | signed |
| 4/28 | Dominic Rhodes | RB | cut |
| 4/23 | Michael Waddell | CB | signed/unrestricted free agent |
| 4/23 | Jarrod Cooper | S | re-signed/unrestricted free agent |
| 4/15 | Duane Starks | CB | signed, One-year contract |
| 4/1 | John Wade | C | signed/unrestricted free agent |
| 3/25 | Jeff Otis | QB | signed |
| 3/21 | DeAngelo Hall | CB | signed, Seven-year contract |
| 3/20 | DeAngelo Hall | CB | traded, For 2008 2nd- and 2009 5th-round picks |
| 3/14 | William Joseph | DT | signed/unrestricted free agent |
| 3/13 | Drew Carter | WR | signed/unrestricted free agent, One-year contract |
| More Transactions |
| Posted Thu Sep 04 18:25:57 EDT 2008 |
