| Date | Player | Pos. | Transaction |
| 10/6 | Dylan Gandy | G | cut |
| 10/6 | Chad Mustard | TE | signed |
| 9/30 | Clifford Russell | WR | Placed on IR, sprained neck |
| 9/30 | Glenn Martinez | WR | signed/unrestricted free agent |
| 9/24 | Dylan Gandy | G | signed |
| 9/24 | Josh Bell | CB | practice squad addition |
| 9/23 | Hamza Abdullah | S | cut |
| 9/23 | Tom Nalen | C | Placed on IR, knee |
| 9/23 | Travis Wilson | WR | practice squad deletion |
| 9/23 | Vernon Fox | S | signed |
| 9/17 | Clifford Russell | WR | signed |
| 9/10 | Al Wilson | LB | retired |
| 9/9 | Brandon Marshall | WR | suspension lifted |
| 9/9 | Dylan Gandy | G | cut |
| 9/6 | D.J. Williams | LB | signed, Five-year extension (through 2013) |
| 9/4 | Cecil Sapp | RB | Taken off IR, left quadriceps |
| 9/4 | Cecil Sapp | RB | cut |
| 9/3 | Travis Wilson | WR | practice squad addition |
| 9/3 | Roderick Rogers | S | practice squad addition |
| 9/3 | P.J. Pope | RB | practice squad addition |
| 9/3 | Ryan McBean | DE | practice squad addition |
| 9/3 | Steven Harris | DT | practice squad addition |
| 9/3 | Darrell Hackney | QB | practice squad addition |
| 9/3 | Mitch Erickson | G | practice squad addition |
| 9/3 | Josh Barrett | S | practice squad addition |
| 9/2 | Alvin McKinley | DT | cut |
| 9/2 | Josh Shaw | DT | signed |
| 9/2 | Dylan Gandy | G | re-signed |
| 9/1 | Calvin Lowry | S | acquired from waivers |
| 8/26 | Carlton Powell | DT | Placed on the physically unable to perform list |
| 8/26 | Taylor Jacobs | WR | cut |
| 8/25 | Josh Mallard | DE | cut |
| 8/25 | Samie Parker | WR | cut |
| 8/13 | Tyrone Poole | CB | signed |
| 8/13 | Christian Morton | CB | cut |
| 8/12 | Wale Dada | CB | signed |
| 8/12 | Lamont Reid | CB | cut |
| 8/5 | Brandon Marshall | WR | suspended, 3 games (NFL conduct policy) |
| 8/3 | Vickiel Vaughn | S | signed |
| 7/27 | Taylor Jacobs | WR | re-signed |
| 7/26 | Edell Shepherd | WR | Placed on IR, left leg/knee |
| 7/25 | Ryan Clady | T | signed/draft choice, Five-year contract |
| 7/24 | Rod Smith | WR | retired |
| 7/24 | Eddie Royal | WR | signed/draft choice, Four-year contract |
| 7/22 | Jack Williams | CB | signed/draft choice |
| 7/21 | Mike Bell | RB | cut |
| 7/21 | Kory Lichtensteiger | G | signed/draft choice |
| 7/16 | Peyton Hillis | RB | signed/draft choice |
| 7/9 | Carlton Powell | DT | signed/draft choice |
| 7/9 | Ryan Torain | RB | signed/draft choice |
| 7/9 | Spencer Larsen | LB | signed/draft choice |
| 6/13 | Brandon Archer | LB | cut |
| 6/13 | Taylor Jacobs | WR | cut |
| 6/13 | Cullen Finnerty | QB | cut |
| 6/13 | Danny Baugher | P | cut |
| 6/13 | Vickiel Vaughn | S | cut |
| 6/13 | Julian Jenkins | DT | cut |
| 6/12 | Josh Barrett | S | signed/draft choice |
| 6/2 | Travis Henry | RB | cut |
| 5/28 | Marviel Underwood | S | cut |
| 5/27 | Michael Pittman | RB | signed/unrestricted free agent, One-year contract |
| 4/24 | Dewayne Robertson | DT | traded, For conditional 2009 draft pick |
| 4/24 | Norm Katnik | C | cut |
| 4/17 | Darrell Jackson | WR | signed, One-year contract |
| 4/15 | Danny Baugher | P | signed |
| 4/15 | Samie Parker | WR | signed/unrestricted free agent |
| 4/15 | Derrick Hamilton | WR | cut |
| 4/15 | Chad Upshaw | TE | cut |
| 4/14 | Antwon Burton | DT | cut |
| More Transactions |
| Posted Wed Oct 08 23:55:18 EDT 2008 |
