| Last updated: Thu, December 4, 2008, 20:32 EST |
| Date | Player | Pos. | Transaction |
| 12/3 | Trever Miller | P | Signed as Free Agent, ( 2009) |
| 11/20 | Trever Miller | P | Signed as Free Agent, ( 2009) |
| 11/20 | Mike Parisi | P | Outrighted to Minors |
| 11/10 | Juan Encarnacion | RF | Removed From 60-Day DL, (Recovery from fractured eye socket) |
| 11/10 | Juan Encarnacion | RF | Declared Free Agency |
| 11/4 | Mark Mulder | P | Removed From 60-Day DL, (Left shoulder strain) |
| 11/4 | Jason LaRue | C | Signed as Free Agent, ( 2009) |
| 11/4 | Mark Mulder | P | Declared Free Agency, (team option declined) |
| 11/1 | Jason Isringhausen | P | Removed From 60-Day DL, (Torn tendon, right elbow- out for season) |
| 11/1 | Jason Isringhausen | P | Declared Free Agency |
| 10/31 | Jason LaRue | C | Signed as Free Agent, ( 2009) |
| 10/30 | Ron Villone | P | Declared Free Agency |
| 10/30 | Russ Springer | P | Declared Free Agency |
| 10/30 | Felipe Lopez | 2B | Declared Free Agency |
| 10/30 | Braden Looper | P | Declared Free Agency |
| 10/30 | Jason LaRue | C | Declared Free Agency |
| 10/30 | Cesar Izturis | SS | Declared Free Agency |
| 10/23 | Mark Johnson | C | Outrighted to Minors |
| 10/21 | Mark Mulder | P | Not Offered Contract and Became Free Agent, (team option declined) |
| 10/15 | Josh Phelps | 1B | Designated for Assignment |
| 10/15 | Charlie Manning | P | Acquired Off Waivers From, Washington |
| 10/8 | Jaime Garcia | P | Removed From 15-Day DL, (Strained left elbow) |
| 10/8 | Joe Mather | RF | Removed From 15-Day DL, (Broken left hand - out for season) |
| 9/29 | Kyle Lohse | P | Signed, ( 2009-2012)(four-year extension) |
| 9/10 | Kyle Lohse | P | Starting to Serve Suspension |
| 9/10 | Brian Barton | LF | Removed From 15-Day DL, (Strained right oblique) |
| 9/2 | Rico Washington | 3B | Called Up from Minors, - Not to Report |
| 9/2 | Rico Washington | 3B | Outrighted to Minors |
| 9/2 | Jason Isringhausen | P | Transferred to 60-Day DL, (Torn tendon, right elbow- out for season) |
| 9/2 | Chris Duncan | LF | Transferred to 60-Day DL, (Herniated disc surgery - out for season) |
| 9/2 | Brian Barden | 3B | Purchased From Minors |
| 9/2 | Mark Johnson | C | Purchased From Minors |
| 9/2 | Kelvin Jimenez | P | Called Up from Minors |
| 9/2 | Brendan Ryan | SS | Called Up from Minors |
| 9/2 | Jason Motte | P | Called Up from Minors |
| 9/2 | Josh Kinney | P | Removed From 60-Day DL, (Recovery from right elbow surgery) |
| 9/2 | Josh Kinney | P | Recalled From Minors, Rehab Assignment |
| 9/1 | Randy Flores | P | Called Up from Minors |
| 9/1 | Chris Carpenter | P | Removed From 15-Day DL, (Shoulder strain) |
| 8/27 | Josh Phelps | 1B | Purchased From Minors |
| 8/27 | Mark Mulder | P | Transferred to 60-Day DL, (Left shoulder strain) |
| 8/27 | Jaime Garcia | P | Sent to Minors |
| 8/26 | Nick Stavinoha | LF | Called Up from Minors |
| 8/26 | Brian Barton | LF | Placed on 15-Day DL, (Strained right oblique) |
| 8/24 | Josh Kinney | P | Sent to Minors, For Rehabilitation |
| 8/22 | Adam Wainwright | P | Recalled From Minors, Rehab Assignment |
| 8/22 | Adam Wainwright | P | Removed From 15-Day DL, (Sprained right middle finger) |
| 8/22 | Jason Isringhausen | P | Placed on 15-Day DL, (Torn tendon, right elbow- out for season) |
| 8/20 | Kyle Lohse | P | Suspension Announced By League, (five games) |
| 8/15 | Brian Barton | LF | Recalled From Minors, Rehab Assignment |
| 8/15 | Brian Barton | LF | Removed From 15-Day DL, (Deep bone bruise, right wrist) |
| 8/15 | Chris Carpenter | P | Placed on 15-Day DL, (Shoulder strain) |
| 8/8 | Adam Wainwright | P | Sent to Minors, For Rehabilitation |
| 8/6 | Chris Perez | P | Called Up from Minors |
| 8/6 | Felipe Lopez | 2B | Signed as Free Agent, ( 2008) |
| 8/6 | Nick Stavinoha | LF | Sent to Minors |
| 8/6 | Brendan Ryan | SS | Sent to Minors |
| 8/2 | Matt Clement | P | Removed From 15-Day DL, (Recovery from right shoulder surgery) |
| 8/2 | Matt Clement | P | Recalled From Minors, Rehab Assignment |
| 8/2 | Matt Clement | P | Released |
| 8/1 | Jaime Garcia | P | Called Up from Minors |
| 8/1 | Kelvin Jimenez | P | Sent to Minors |
| 7/30 | Randy Flores | P | Sent to Minors |
| 7/30 | Chris Carpenter | P | Removed From 60-Day DL, (Recovery from right elbow surgery) |
| 7/30 | Chris Carpenter | P | Recalled From Minors, Rehab Assignment |
| 7/28 | Nick Stavinoha | RF | Called Up from Minors |
| 7/28 | Mitchell Boggs | P | Sent to Minors |
| 7/26 | Anthony Reyes | P | Called Up from Minors, - Not to Report |
| 7/22 | Joe Mather | RF | Called Up from Minors |
| 7/22 | Chris Duncan | LF | Placed on 15-Day DL, (Pinched nerve in back) |
| 7/21 | Mitchell Boggs | P | Called Up from Minors |
| 7/21 | Jaime Garcia | P | Sent to Minors |
| 7/20 | Chris Carpenter | P | Sent to Minors, For Rehabilitation |
| 7/18 | Kelvin Jimenez | P | Called Up from Minors |
| 7/18 | Randy Flores | P | Removed From 15-Day DL, (Left ankle peroneal tendinitis) |
| 7/18 | Randy Flores | P | Recalled From Minors, Rehab Assignment |
| 7/18 | Joe Mather | RF | Sent to Minors |
| 7/18 | Chris Perez | P | Sent to Minors |
| 7/10 | Jaime Garcia | P | Purchased From Minors |
| 7/10 | Mark Mulder | P | Placed on 15-Day DL, (Left shoulder strain) |
| 7/8 | Randy Flores | P | Sent to Minors, For Rehabilitation |
| 7/6 | Cesar Izturis | SS | Removed From 15-Day DL, (Strained right hamstring) |
| 7/6 | Mitchell Boggs | P | Sent to Minors |
| 7/6 | Brian Barton | LF | Placed on 15-Day DL, (Deep bone bruise, right wrist) |
| 7/6 | Joe Mather | RF | Called Up from Minors |
| 7/5 | Anthony Reyes | P | Recalled From Minors, Rehab Assignment |
| 7/5 | Anthony Reyes | P | Removed From 15-Day DL, (Right elbow strain) |
| 7/5 | Anthony Reyes | P | Sent to Minors |
| 7/2 | Anthony Reyes | P | Sent to Minors, For Rehabilitation |
| 6/30 | Brad Thompson | P | Called Up from Minors |
| 6/30 | Nick Stavinoha | RF | Sent to Minors |
| 6/27 | Mike Parisi | P | Sent to Minors |
| 6/27 | Mark Mulder | P | Removed From 15-Day DL, (Recovery from left rotator surgery) |
| 6/27 | Mark Mulder | P | Recalled From Minors, Rehab Assignment |
| 6/26 | Albert Pujols | 1B | Removed From 15-Day DL, (Strained left calf - out 3-4 weeks) |
| 6/26 | Randy Flores | P | Placed on 15-Day DL, (Left ankle peroneal tendinitis) |
| 6/22 | Nick Stavinoha | RF | Purchased From Minors |
| 6/22 | Chris Carpenter | P | Transferred to 60-Day DL, (Recovery from right elbow surgery) |
| 6/22 | Cesar Izturis | SS | Placed on 15-Day DL, (Strained right hamstring) |
| 6/20 | Brad Thompson | P | Sent to Minors |
| 6/20 | Mike Parisi | P | Called Up from Minors |
| 6/19 | Anthony Reyes | P | Placed on 15-Day DL, (Right elbow strain) |
| 6/19 | Brad Thompson | P | Recalled From Minors, Rehab Assignment |
| 6/19 | Brad Thompson | P | Removed From 15-Day DL, (Right elbow inflammation) |
| 6/18 | Kelvin Jimenez | P | Sent to Minors, For Rehabilitation |
| 6/15 | Mark Mulder | P | Sent to Minors, For Rehabilitation |
| 6/14 | Jason Isringhausen | P | Removed From 15-Day DL, (Right hand laceration) |
| 6/14 | Jason Isringhausen | P | Recalled From Minors, Rehab Assignment |
| 6/14 | Joe Mather | RF | Sent to Minors |
| 6/14 | Anthony Reyes | P | Called Up from Minors |
| 6/14 | Mark Worrell | P | Sent to Minors |
| 6/12 | Joel Pineiro | P | Removed From 15-Day DL, (Right groin strain) |
| 6/12 | Albert Pujols | 1B | Placed on 15-Day DL, (Strained left calf - out 3-4 weeks) |
| 6/11 | Chris Duncan | LF | Called Up from Minors |
| 6/10 | Adam Wainwright | P | Placed on 15-Day DL, (Sprained right middle finger) |
| 6/10 | Brad Thompson | P | Sent to Minors, For Rehabilitation |
| 6/9 | Jason Isringhausen | P | Sent to Minors, For Rehabilitation |
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