| Date | Player | Pos. | Transaction |
| 7/25 | David Ortiz | DH | Recalled From Minors, Rehab Assignment |
| 7/25 | David Ortiz | DH | Removed From 15-Day DL, (Torn tendon sheath in left wrist) |
| 7/24 | Brandon Moss | RF | Sent to Minors |
| 7/20 | David Aardsma | P | Placed on 15-Day DL, (Strained right groin) |
| 7/20 | Justin Masterson | P | Called Up from Minors |
| 7/17 | David Ortiz | DH | Sent to Minors, For Rehabilitation |
| 7/12 | Jed Lowrie | 3B | Called Up from Minors |
| 7/12 | Julio Lugo | SS | Placed on 15-Day DL, (Strained left quad) |
| 7/11 | Clay Buchholz | P | Called Up from Minors |
| 7/9 | Jeff Bailey | LF | Sent to Minors |
| 7/7 | Justin Masterson | P | Sent to Minors |
| 7/7 | Jeff Bailey | LF | Called Up from Minors |
| 7/3 | Mike Timlin | P | Removed From 15-Day DL, (Left knee tendinitis) |
| 7/3 | Mike Timlin | P | Recalled From Minors, Rehab Assignment |
| 7/3 | Coco Crisp | CF | Reinstated From League Suspension |
| 7/2 | Chris Smith | P | Sent to Minors |
| 6/28 | Coco Crisp | CF | Starting to Serve Suspension |
| 6/27 | Sean Casey | 1B | Reinstated From League Suspension |
| 6/26 | Mike Timlin | P | Sent to Minors, For Rehabilitation |
| 6/23 | Sean Casey | 1B | Starting to Serve Suspension |
| 6/21 | Daisuke Matsuzaka | P | Removed From 15-Day DL, (Mild right rotator cuff strain) |
| 6/21 | Daisuke Matsuzaka | P | Recalled From Minors, Rehab Assignment |
| 6/21 | Mike Timlin | P | Placed on 15-Day DL, (Left knee tendinitis) |
| 6/17 | Bartolo Colon | P | Placed on 15-Day DL, (Back stiffness) |
| 6/16 | Daisuke Matsuzaka | P | Sent to Minors, For Rehabilitation |
| 6/8 | Dave Gassner | P | Signed to a Minor League Contract |
| 6/6 | Brandon Moss | RF | Called Up from Minors |
| 6/6 | Jon Lester | P | Suspension Announced By League, (five games) |
| 6/6 | Coco Crisp | CF | Suspension Announced By League, (seven games) |
| 6/6 | Sean Casey | 1B | Suspension Announced By League, (three games) |
| 6/6 | Chris Carter | 1B | Sent to Minors |
| 6/3 | David Ortiz | DH | Placed on 15-Day DL, (Torn tendon sheath in left wrist) |
| 6/3 | Justin Masterson | P | Called Up from Minors |
| 6/3 | Jeff Bailey | LF | Sent to Minors |
| 5/31 | Clay Buchholz | P | Recalled From Minors, Rehab Assignment |
| 5/31 | Clay Buchholz | P | Removed From 15-Day DL, (Broken nail, right middle finger) |
| 5/31 | Clay Buchholz | P | Sent to Minors |
| 5/30 | Jeff Bailey | 1B | Purchased From Minors |
| 5/30 | Daisuke Matsuzaka | P | Placed on 15-Day DL, (Mild right rotator cuff strain) |
| 5/25 | Clay Buchholz | P | Sent to Minors, For Rehabilitation |
| 5/24 | Brandon Moss | RF | Removed From 15-Day DL, (Appendectomy) |
| 5/24 | Brandon Moss | RF | Recalled From Minors, Rehab Assignment |
| 5/24 | Brandon Moss | RF | Sent to Minors |
| 5/23 | Julian Tavarez | P | Refused Minor League Assignment - Free Agent |
| 5/22 | Brandon Moss | RF | Sent to Minors, For Rehabilitation |
| 5/21 | Justin Masterson | P | Sent to Minors |
| 5/21 | Bartolo Colon | P | Purchased From Minors |
| 5/20 | Justin Masterson | P | Called Up from Minors |
| 5/20 | Julian Tavarez | P | Outrighted to Minors |
| 5/17 | Jonathan Van Every | CF | Sent to Minors |
| 5/14 | Jonathan Van Every | CF | Called Up from Minors |
| 5/14 | Clay Buchholz | P | Placed on 15-Day DL, (Broken nail, right middle finger) |
| 5/12 | Abe Alvarez | P | Released |
| 5/12 | Sean Casey | 1B | Recalled From Minors, Rehab Assignment |
| 5/12 | Sean Casey | 1B | Removed From 15-Day DL, (Right hip flexor strain) |
| 5/12 | Julian Tavarez | P | Designated for Assignment |
| 5/11 | Jed Lowrie | 2B | Sent to Minors |
| 5/11 | Alex Cora | SS | Recalled From Minors, Rehab Assignment |
| 5/11 | Alex Cora | SS | Removed From 15-Day DL, (Sore right elbow) |
| 5/8 | Sean Casey | 1B | Sent to Minors, For Rehabilitation |
| 5/7 | Alex Cora | SS | Sent to Minors, For Rehabilitation |
| 5/5 | Craig Hansen | P | Called Up from Minors |
| 5/5 | Brandon Moss | RF | Placed on 15-Day DL, (Appendectomy) |
| 4/29 | Mike Lowell | 3B | Removed From 15-Day DL, (Sprained left thumb) |
| 4/29 | Bryan Corey | P | Designated for Assignment |
| 4/29 | Mike Lowell | 3B | Recalled From Minors, Rehab Assignment |
| 4/27 | Dan Kolb | P | Released |
| 4/26 | Sean Casey | 1B | Placed on 15-Day DL, (Right hip flexor strain) |
| 4/26 | Brandon Moss | RF | Called Up from Minors |
| 4/25 | Mike Lowell | 3B | Sent to Minors, For Rehabilitation |
| 4/25 | Bryan Corey | P | Purchased From Minors |
| 4/25 | Joe Thurston | 2B | Outrighted to Minors |
| 4/24 | Justin Masterson | P | Sent to Minors |
| 4/24 | Justin Masterson | P | Purchased From Minors |
| 4/23 | David Pauley | P | Sent to Minors |
| 4/23 | Craig Hansen | P | Called Up from Minors |
| 4/23 | Craig Hansen | P | Sent to Minors |
| 4/22 | David Pauley | P | Called Up from Minors |
| 4/22 | Joe Thurston | 2B | Designated for Assignment |
| 4/22 | Bryan Corey | P | Signed to a Minor League Contract |
| 4/17 | Bryan Corey | P | Outrighted to Minors |
| 4/17 | Bryan Corey | P | Refused Minor League Assignment - Free Agent |
| 4/16 | Joe Thurston | 2B | Purchased From Minors |
| 4/15 | Alex Cora | SS | Placed on 15-Day DL, (Sore right elbow) |
| 4/14 | Kyle Snyder | P | Outrighted to Minors |
| 4/11 | Mike Timlin | P | Recalled From Minors, Rehab Assignment |
| 4/11 | Mike Timlin | P | Removed From 15-Day DL, (Contusion, right index finger) |
| 4/11 | Bryan Corey | P | Designated for Assignment |
| 4/10 | Mike Lowell | 3B | Placed on 15-Day DL, (Sprained left thumb) |
| 4/8 | Eric Hull | P | Traded From, Los Angeles (for IF Christian Lara & cash) |
| 4/8 | Eric Hull | P | Sent to Minors |
| 4/7 | Mike Timlin | P | Sent to Minors, For Rehabilitation |
| 4/6 | Kyle Snyder | P | Designated for Assignment |
| 4/6 | Josh Beckett | P | Removed From 15-Day DL, (Recurring back spasms) |
| 3/26 | Brandon Moss | LF | Sent to Minors |
| 3/24 | Josh Beckett | P | Placed on 15-Day DL, (Recurring back spasms) |
| 3/24 | Kevin Cash | C | Purchased From Minors |
| 3/17 | Craig Hansen | P | Sent to Minors |
| 3/13 | Curt Schilling | P | Placed on 60-Day DL, (Right biceps degeneration-out 4-6 months) |
| 3/13 | Devern Hansack | P | Sent to Minors |
| 3/13 | Doug Mirabelli | C | Released |
| 3/8 | David Pauley | P | Sent to Minors |
| 2/25 | Bartolo Colon | P | Signed to a Minor League Contract |
| 2/10 | Kevin Youkilis | 1B | Signed, ( 2008)(avoids arbitration) |
| 2/5 | Bobby Kielty | RF | Signed to a Minor League Contract |
| 2/5 | Matt Miller | P | Signed to a Minor League Contract |
| 2/1 | Sean Casey | 1B | Signed as Free Agent, ( 2008) |
| More Transactions |
| Posted Sat Jul 26 15:32:49 EDT 2008 |