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| All Designated Hitters Projected 2008 Stats |
| Player | Team | P | AB | R | H | 1B | 2B | 3B | HR | RBI | BB | KO | SB | CS | BA | OBP | SLG | FPTS |
| Ortiz, David | BOS | DH | 550 | 114 | 167 | 83 | 40 | 0 | 44 | 134 | 110 | 110 | 3 | 1 | 0.3036 | 0.4197 | 0.6164 | 592.0 |
| Guerrero, Vladimir | ANA | RF | 550 | 100 | 179 | 110 | 33 | 1 | 35 | 116 | 59 | 59 | 7 | 3 | 0.3255 | 0.3908 | 0.5800 | 546.0 |
| Hafner, Travis | CLE | DH | 528 | 95 | 153 | 80 | 40 | 1 | 32 | 110 | 100 | 125 | 1 | 0 | 0.2898 | 0.4029 | 0.5511 | 473.0 |
| Matsui, Hideki | NYY | LF | 548 | 100 | 154 | 94 | 33 | 2 | 25 | 100 | 70 | 75 | 3 | 2 | 0.2810 | 0.3625 | 0.4854 | 465.0 |
| Damon, Johnny | NYY | CF | 525 | 95 | 148 | 97 | 35 | 4 | 12 | 60 | 56 | 70 | 20 | 7 | 0.2819 | 0.3511 | 0.4324 | 401.0 |
| Sheffield, Gary | DET | DH | 429 | 80 | 127 | 85 | 20 | 0 | 22 | 75 | 72 | 60 | 11 | 4 | 0.2960 | 0.3972 | 0.4965 | 398.0 |
| Giambi, Jason | NYY | DH | 446 | 78 | 112 | 53 | 28 | 0 | 31 | 90 | 100 | 110 | 0 | 1 | 0.2511 | 0.3883 | 0.5224 | 390.0 |
| Huff, Aubrey | BAL | 1B | 552 | 70 | 157 | 97 | 37 | 3 | 20 | 80 | 50 | 83 | 2 | 2 | 0.2844 | 0.3439 | 0.4710 | 379.0 |
| Thome, Jim | CHW | DH | 427 | 75 | 120 | 63 | 25 | 0 | 32 | 90 | 90 | 130 | 0 | 0 | 0.2810 | 0.4062 | 0.5644 | 366.0 |
| Butler, Billy | KC | DH | 559 | 65 | 160 | 102 | 40 | 0 | 18 | 87 | 52 | 94 | 0 | 0 | 0.2862 | 0.3470 | 0.4544 | 364.0 |
| Thomas, Frank | TOR | DH | 427 | 60 | 117 | 74 | 18 | 0 | 25 | 90 | 70 | 80 | 0 | 0 | 0.2740 | 0.3763 | 0.4918 | 350.0 |
| Anderson, Garret | ANA | LF | 434 | 70 | 129 | 83 | 30 | 0 | 16 | 81 | 25 | 65 | 1 | 1 | 0.2972 | 0.3355 | 0.4770 | 319.0 |
| Kubel, Jason | MIN | LF | 465 | 66 | 125 | 80 | 29 | 0 | 16 | 70 | 50 | 90 | 6 | 3 | 0.2688 | 0.3398 | 0.4344 | 307.0 |
| Millar, Kevin | BAL | 1B | 428 | 55 | 116 | 77 | 25 | 0 | 14 | 60 | 64 | 75 | 0 | 0 | 0.2710 | 0.3659 | 0.4276 | 287.0 |
| Cust, Jack | OAK | LF | 405 | 60 | 100 | 58 | 17 | 0 | 25 | 80 | 94 | 157 | 0 | 0 | 0.2469 | 0.3888 | 0.4741 | 269.0 |
| Gomes, Jonny | TB | LF | 433 | 65 | 105 | 57 | 23 | 2 | 23 | 65 | 60 | 139 | 10 | 5 | 0.2425 | 0.3347 | 0.4642 | 267.0 |
| Vidro, Jose | SEA | DH | 396 | 45 | 115 | 84 | 25 | 1 | 5 | 40 | 41 | 41 | 0 | 0 | 0.2904 | 0.3570 | 0.3965 | 242.0 |
| Gibbons, Jay | BAL | LF | 331 | 40 | 86 | 51 | 21 | 0 | 14 | 45 | 26 | 47 | 0 | 0 | 0.2598 | 0.3137 | 0.4502 | 213.0 |
| Sosa, Sammy | TEX. | DH | 401 | 45 | 99 | 63 | 20 | 0 | 16 | 65 | 35 | 100 | 0 | 0 | 0.2469 | 0.3073 | 0.4165 | 212.0 |
| Duncan, Shelley | NYY | DH | 329 | 49 | 84 | 48 | 20 | 0 | 16 | 55 | 35 | 85 | 0 | 0 | 0.2553 | 0.3269 | 0.4620 | 206.0 |
| Piazza, Mike | OAK | DH | 285 | 30 | 80 | 55 | 13 | 0 | 12 | 45 | 25 | 50 | 0 | 0 | 0.2807 | 0.3387 | 0.4526 | 179.0 |
| Sweeney, Mike | KC | DH | 254 | 30 | 71 | 46 | 15 | 0 | 10 | 39 | 20 | 37 | 0 | 1 | 0.2795 | 0.3321 | 0.4567 | 167.0 |
| Tyner, Jason | MIN | LF | 240 | 35 | 66 | 55 | 10 | 1 | 0 | 19 | 14 | 20 | 5 | 2 | 0.2750 | 0.3150 | 0.3250 | 134.0 |
| Norton, Greg | TB | DH | 199 | 25 | 50 | 31 | 11 | 0 | 8 | 30 | 26 | 50 | 1 | 2 | 0.2513 | 0.3378 | 0.4271 | 116.0 |
| Jones, Garrett | MIN | DH | 194 | 18 | 52 | 35 | 11 | 1 | 5 | 20 | 17 | 45 | 0 | 0 | 0.2680 | 0.3270 | 0.4124 | 90.0 |
| Durazo, Erubiel | OAK | DH | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0000 | 0.0000 | 0.0000 | 0.0 |
| White, Rondell | MIN | DH | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0000 | 0.0000 | 0.0000 | 0.0 |